31 In a phase II clinical trial of ABT-510, which is a peptide mimetic of thrombospondin type 1 (yet another endogenous angiogenesis inhibitor), only 3 out of 21 late-stage malignant melanoma patients showed stable disease, and no definite clinical efficacy was demonstrated.
As this study was designed to show the safety of Canephron® N treatment, it is not possible to give a definite statement about efficacy, but the fast symptomatic resolution of uUTI under Canephron® N treatment hints at the efficacy of Canephron® N that needs to be further investigated.
In short, a definite conclusion on efficacy of acupuncture for GDP can not be drawn from this review because of the low methodological quality of the included trials.
5, 6, 11, 16 Thus, the relative "under use" of evidence based treatments largely appears to depend on the higher complexity and the lack of definite evidence on efficacy and safety of nonpharmacological and pharmacological treatments in the very elderly.
17 18 None of the individual clinical trials on SGLT-2i provide definite conclusions regarding efficacy and safety, and so far the current guidelines for the management of type 2 diabetes do not include SGLT-2i.
The definite confirmation of efficacy of NovoTTF-100A will be obtained by an ongoing multicenter phase III trial that randomizes over 800 patients with newly diagnosed GBM to undergo standard radiotherapy with concomitant and adjuvant TMZ versus standard radiotherapy plus NovoTTF and adjuvant TMZ treatment.
In view of the poor methodological quality of the included studies, it is difficult to draw any definite conclusions about the efficacy or lack of efficacy of diet and physical activity interventions for pregnant women and therefore guide clinical practice and policy making.
It is difficult to draw definite conclusions about the efficacy of RFA, as most published data consist of non-randomized uncontrolled cohort studies.
The uncontrolled, retrospective nature of our study precludes definite conclusions about the efficacy or safety of dexmedetomidine for severe alcohol withdrawal.
