It should be mentioned that the criteria to differentiate no-reflow zones from mural thrombi are not definite, and thus differentiation may not always be straightforward.
At the best of our knowledge, this is the only genosensor so far described that allows the discrimination of L. monocytogenes from different nonpathogenic Listeria strains based on the detection of a specific listerial pathogenic factor such as internalin A. It proved to allow a definite and significant differentiation of pathogenic from nonpathogenic listerial species.
The cells were colonized and grown like normal undifferentiated ES cells under the maintenance of Oct-4 transgene expression; however, upon treatment with doxycycline, a tetracycline analogue, as previously reported [ 12, 24], definite morphological changes towards differentiation occurred as time elapsed.
Not definitive, just definite.
Following differentiation towards a definite lineage, a stem cell must downregulate pluripotency genes definitively, activate expression of genes for the necessary differentiation phenotype, and lock differentiation genes for other lineages into a silent state.
In summary, drug treatment for 4 days was sufficient to trigger the definite deviation from the normal differentiation path.
Because only semiquantitative analysis of lower respiratory secretions were available, differentiation between microbiologically definite and probable pneumonia was not possible in all patients.
Hybridization of nanofibers with biomimetic calcium phosphates is another avenue, in which the osteoconductive properties of polymers can be improved and polymer matrix resorption and degradation can be tailored with definite enhancements in cell adhesion, proliferation and differentiation.
All the cells further differentiated into the definite neural epithelial cells at days 14 17, and these neural progenitor cells were plated onto ornithine/laminin-coated coverslips at day 24 for terminal differentiation.
Presence of multiple patterns of malignant salivary gland type tumours or diverse differentiation alone was not accepted as definite evidence of Ca ex PSA.
