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It is difficult to make any definite comments; however, the current results suggest that patients with small and solitary metastatic liver tumor of MCC may achieve long-term survival following hepatic resection, and hepatic resection may be justified for these patients.
Definite comments about adverse effects were reported in only three studies.
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27 We have not provided definite comment on the threshold of absolute risk that should be used for intervention, as that would require cost-effectiveness analyses which are outside the scope of this study.
We have not provided definite comment on what threshold of absolute risk should be used for intervention, as that would include cost effectiveness analyses, which are outside the scope of this study.
Although we have provided analysis of several thresholds for illustrative purposes, we have not provided definite comment on what threshold of absolute risk should be used to define a "high risk" group, as that would require consideration of the balance of risks and benefits for individuals and cost effectiveness analyses, which are outside the scope of this study.
We have not provided definite comment on what threshold of absolute risk should be used for intervention or avoiding anticoagulants as that would require consideration of the balance of risk and benefit for an individual and their choice and require cost-effectiveness analyses, which are outside the scope of this study.
We have not provided definite comment on what threshold of absolute risk should be used to define a "high risk" group as that would require (1) the balance of risks and benefits for individuals and (2) cost-effectiveness analyses which are outside the scope of this study.
79 However, in this paper, we have not provided definite comment on what threshold of absolute risk should be used to define 'high risk' since that would require (1) consideration of the balance of risk/benefit for an individual and their choice and (2) cost-effectiveness analyses which are outside the scope of this study.
Within these definite boundaries, some further comments can be made.
However, as time to approval consisted of time attributable to RECs and time used by researchers to respond to comments, no definite conclusions can be drawn.
Not definitive, just definite.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com