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The four categories were: 1) absence of CAP hereafter referred to as excluded CAP diagnosis; 2) possible CAP; 3) probable CAP; and 4) definite CAP.
In our study, although CRP seems more discriminating than PCT, neither the experimental exclusion of extra-pulmonary bacterial infections from the excluded CAP group, nor the exclusion of viral CAP from the definite CAP patients group, made possible the determination of a discriminant cutoff.
The performances of CRP and PCT in predicting definite CAP were evaluated by sensitivity analysis (definite CAP vs excluded CAP).
Indeed, clinical presentation of excluded CAP patients was similar to that of definite CAP patients except for fever and cough that were more frequent in definite CAP patients.
(DOC 24 kb) Additional file 2: Bacterial and viral data for patients with definite CAP.
A statistically significant difference between the two groups (excluded CAP vs definite CAP) was demonstrated for several cut-off points for CRP and PCT (Table 2).
Similar(44)
In total, 925 patients had the definite diagnosis of CAP.
Patients had to be over 18 years old with a definite diagnosis of CAP to be eligible for this analysis.
This pooled analysis includes 82 patients with the definite diagnosis of Legionella CAP and 368 patients with non- Legionella CAP.
We measured baseline serum procalcitonin (PCT), C reactive protein (CRP), and white blood cell (WBC) count in 171 patients with CAP with definite etiology admitted to a tertiary hospital: 59 (34.5%) bacterial, 66 (39.%) viral and 46 (27%) mixed (viral-bacterial).
Not definitive, just definite.
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