As shown in the third and seventh columns in Table 4, a definite connectivity between the activation free energy (Δ G⧧) and the corresponding HEBDE was observed.
Although stimulation of melanoma N1 cells (GD3+ and GD3−) with either HGF or adhesion to CL-I did not show marked differences in the phosphorylation levels of Akt at Ser473 and Thr308 between two types of cells, simultaneous treatment resulted in definite and markedly increased activation of Akt in GD3+ cells.
Not definitive, just definite.
Furthermore, various cytokines (e.g., IL-15 and IL-17) are involved in signaling pathways in which ULBP1 takes part, although definite mechanisms and signals regulating their activation remain to be elucidated.
Nonetheless, a definite role of p38 MAPK in CAR activation has yet to be established, given that activation of p38 MAPK appears to enhance some but not all target genes of hCAR.
It must be pointed out that nonlinear time series analyses cannot provide a definite answer regarding the nature of spike activation and interspike times in the system.
Since these interactions have been experimentally measured they can be associated with a definite direction of the causal effect, either activation or inhibition of the above mentioned processes at a whole genome network-wide level.
Although MALT1 is well known to activate NF- κB in lymphocyte lineages (McAllister-Lucas et al, 2011), there was no definite predisposition for genes involved in NF- κB activation (Supplementary Figure 3).
Again, none of the investigated activation markers contributed to the definition of the disease subset (that is, early SSc, definite SSc, UCTD).
The study design (a longitudinal observational study without a control group) prohibits definite conclusions about the causal relationship between temperature and activation of the innate immune response after cardiac arrest.
