These outcomes provide insights into the importance of multiple factors in defining the selectivity of these receptors, including the presence of conformationally defined units in some oligosaccharide ligands, local and extended interactions between glycans and the surfaces of receptors, and steric factors that exclude binding of some ligands.
Solving the structure and defining the selectivity of Bcl-B delimits the role of one of the few remaining Bcl-2 family members without these data, both setting Bcl-B in the context of the Bcl-2 family and declaring Bim as the singular universal prosurvival protein antagonist.
We defined the selectivity score of a single-drug "A" (selectivityA) as log2 IC50A,alb / IC50A,cer), such that a score of 0 indicates no selectivity, and a score of 1 (or −1) denotes that twice (or half) as much drug is required to inhibit C. albicans compared to S. cerevisiae.
[5] defined the selectivity of the neuron as a function of the area under the tuning curve of the neuronal responses to S. This definition, however, assumes that the learning rule converges to a stable steady state.
In addition to the aforementioned S. cerevisiae intergenic file GIMSAN was given the following parameters --w = 11,17 --oops --t = 200 --L = 200 --nullset = 0 --markov = 4 We define the selectivity of a motif as its ability to distinguish between sites generated according to the motif model (PWM in this case) and sites occurring in "random DNA".
To quantify a selective response of a cancer cell line with respect to a control normal cell line, we define the selectivity S of a single drug or drug combination as S = v N v C where v N indicates the viability of normal cells (IMR90) after treatment, and v C the viability of cancer cells (A549) after treatment.
Using site-directed mutagenesis at these positions and engineered cross-homolog chimeras, we show that Val367, at the periplasmic end of transmembrane helix XI, contributes in defining the substrate selectivity profile.
Components of the sensor like electrodes, and intermediate matrix between the recognition layer and transducer play an important role in defining the stability, selectivity and specificity of biosensor [2].
Potassium ions moving from the inside to the outside of a cell through a potassium channel first move into a water-filled cavity within the channel and then pass through the narrow selectivity filter that defines the ion selectivity of the filter before being released to the outside.
Thus, selectivity coefficient (K i,j ) was used to define the response selectivity of one sensor electrode to target ions, and K i,j can be calculated by the matched potential method (MPM) from the following equation: K i,j = a i /a j.
We defined the rhomboid selectivity as the ratio of IC50 against chymotrypsin IC50 against AarA.
