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The above findings suggest that longer exposure is not suitable for defining the mode of action of drugs.
Collectively, these structures represent an important contribution to the field by defining the mode of interaction between the coiled coil regions of Rabex-5 and Rabaptin-5, identifying alternative conformational states and interactions with the substrate site that may have a functional role, and providing an overview of the quaternary organization of the active complex with a substrate Rab.
In toxicology, however, the application of the high-throughput screening is quite different: The ultimate outcome is lack of activity for key toxicity targets—a lack of activity that may ultimately be used as an indicator of lack of hazard or to assist in defining the mode of action.
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Organisational conditions are becoming increasingly relevant in defining the modes of control.
It is understandable therefore that there has been intense interest in defining the modes of migration employed by cells in vivo.
The original figure is from Latapy (Latapy et al. 2008), this one is redrawn by the author.Due to the existence of different types of relations in the data set, social network analysts have defined the mode of a network.
These mechanisms define the mode of genetic transmission between generations and govern the distribution of genetic variation not only within and among populations but also in effective population size and in the degree to which populations diverge due to natural selection or genetic drift (Holsinger 2000).
Although Kasuya did not explicitly define the mode of nutrition for A. coccinea, most Phallaceae species are suspected to be saprobic decomposers of wood and plant organic matter.
In contrast, the off-target signature defines the mode of action for each modulator used, which has to be not necessarily limited to the inhibition of TGF-βR1 only.
To define the mode of action for these acridine derivatives leading to inhibition of TBSV RNA accumulation, we took advantage of efficient in vitro replication assays developed for tombusviruses.
Several studies have sought to define the mode of DES action on a cellular level.
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