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Defining the determinants of Treg-mediated regulation of allogeneic immune responses is essential for therapeutic application of Tregs in transplantation tolerance and control of GVHD [28], [29], [47], [48].
With the current study we have progressed toward defining the determinants of resistance by establishing that resistance and sensitivity to a prototypical hydroxamate HDACi can be modeled in DLBCL cell lines which express genes significantly associated with poor prognosis in DLBCL patients.
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The factor of two in the power of det ( L ) on the right-hand side of (10) is due to the difference in defining the determinant of a lattice.
Alanine-scanning was used to define the determinants of the interaction between the peptides and tRNALys3.
Macrophages and DCs in particular are key mediators of immune responses, and are widely-used as prototypes to understand and define the determinants of specific and inducible gene expression.
In the current study, we sought to define the determinants of inhibited PRE-dependent HIV-1 Gag assembly and budding in human cells and to test whether altering these determinants can alleviate this block.
We have begun to define the determinants of epigenetic activity of the GFP-COP1 loci.
Further studies designed to define the determinants of risk for acquiring salmonella bacteremia are warranted.
However, studies to date have been underpowered to formally define the determinants of feed intolerance.
To define the determinants of teachers' intention to identify HR students, 75 teachers from secondary and further education institutions in 12 counties surrounding Cambridgeshire completed the questionnaire.
Pharmacokinetic/pharmacodynamic research models offer promising approaches to define the determinants of resistance selection and drug doses that optimize efficacy and reduce resistance selection.
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