A significant development that facilitated the appreciation of the physiological importance of PTEN has been the generation of sophisticated animal models to define the consequences of the loss of function of this phosphatase [ 9].
Further studies are required to define the consequences of the inappropriate use of reporting recommendations in clinical and epidemiological research, in particular the use of these checklists as an instrument to assess the methodological quality of studies.
To molecularly define the consequences of BRDT inhibition by JQ1, we performed genome-wide expression analysis of males treated with 50 mg/kg JQ1 daily for 6 weeks (6 12 weeks of age).
To further define the consequences of astrocytes on GSCs, gene expression profiles were generated from NSC11 and GBAM1 cells grown alone (monoculture) and compared to those generated 48 h after the initiation of coculture with astrocytes.
Moreover, additional studies are needed to define the consequences of ABCD3 overexpression in AA prostate tumors; however due to the intrinsic role of ABCD3 in fatty acid beta oxidation, this would imply that ABCD3 could have a role in enhanced growth in both BPH and malignant cells.
Studies in this yeast have also defined the consequences of several mutations in isoform-1 of the ADP/ATP translocase [adenine nucleotide transporter isoform 1 (ANT1)] that have been associated with various diseases, including autosomal dominant PEO and hypertrophic cardiomyopathy (Kaukonen et al., 2000; Liu and Chen, 2013).
Thus, to define the consequence of the genetic switch to cyclin D1b on retinal phenotypes, expression of individual cyclin D1 isoforms was initially characterized in whole-eye lysates.
Collectively, these data are the first to define the consequence of cyclin D1b expression on normal cellular function, present evidence for cyclin D1b as an oncogene, and provide pre-clinical evidence of effective methods to thwart growth of cells dependent upon this oncogenic variant.
The importance of defining the molecular consequences of LRRK2 inhibition is elevated due to this lack of a therapeutic window for LRRK2 drugs that reduce neuropathology and disease while avoiding peripheral effects.
Efforts toward defining the functional consequences of the change in acetylation of these proteins by HDAC8 are ongoing.
