Sentence examples for defining specificity from inspiring English sources
In addition to producing a stronger machine-learning model for the prediction of calpain cleavage, we were able to highlight the importance and role of each feature of substrate sequences in defining specificity: primary sequence, secondary structure and solvent accessibility.
It is possible that these proteins participate in similar activities, with certain residues in the cavity defining specificity of the ligand.
The preeminent technique for defining specificity is glycan array screening, in which a glycan-binding protein (GBP) can be simultaneously screened against multiple glycans.
Positions 2 to 8 of the 5'end of a mature miRNA have been shown to be most critical for defining specificity [ 21], and we refer to this particular region as a miRNA seed in this study.
Although such interactions involving the main-chain atoms of the substrate (or inhibitor) are not directly responsible for defining specificity, they are likely to be of great importance in correctly positioning the substrate backbone in relation to the catalytic residues.
This observation suggests a significant role for the rest of the inhibitor molecule in defining specificity and selectivity to the molecular drug target by means of multiple drug target interactions.
CsrA has a clearly defined specificity based on binding to a specific mRNA sequence to inhibit translation.
The variants have a defined specificity, as they could be shown to specifically target galactose-decorated xyloglucan structures (such as XLLG).
The multi-epitope contraceptive vaccines and preformed engineered antibodies of defined specificity may eliminate concern related to inter-individual variability of the immune response.
T lymphocytes can be redirected to recognize a tumor target and harnessed to combat cancer by genetic introduction of T-cell receptors of a defined specificity.
In this method, a sVD of a defined specificity is genetically fused to either the N-terminus of the light chain or the C-terminus of the heavy chain of a functional IgG antibody of a different specificity.
