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Change in steroid dosage was taken into consideration while defining progression.
Development of this system entailed devising definitions for visual field defects encountered in NAION patients using an iterative process and expert panel and defining progression.
There is therefore an urgent need to find predictive biomarkers that can aid in defining progression likelihood of LGDs, which represent the majority of diagnosed OPLs.
There are no standard regulatory criteria for defining progression in clinical trials 2 and progression can be difficult to assess and subject to measurement error and bias, especially if assessors are not blinded to treatment.
Shown are the proportions of patients considered to be progressors, using two different smallest detectable differences (SDDs) as cutoff values for defining progression (0.3 mm and 0.5 mm) for the two readers and three views.
Many studies have used a doubling of serum creatinine, corresponding to an approximate halving of GFR, as an end-point defining progression, but this is insufficiently sensitive to be useful in clinical practice.
Similar(51)
But there was a recognized path, a defined progression, a road map from here to there.
In an effort to make the interpretation more standardised, the Prostate Cancer Clinical Trials Working Group (PCWG2) has defined progression in bone as the presence of two or more new lesions on a bone scan compared with a prior scan [10].
That most of the functional categories were assigned to one of these temporal peak patterns indicates a fairly defined progression of functions across the day.
Thus, although a precise discrimination across groups is limited by evidence of overlap of close disease strata, the emphasis is placed on the dosing of multiple protective and risk alleles that define progression.
The Pa O2/Fi O2 ratio defined progression from ALI to ARDS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com