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Along with classic components, this approach explicitly considers additional concerns, defining modules which crosscut traditional barriers.
Simply defining modules based on "strong" versus "mild" induction or repression, without subdividing modules by temporal patterns, does not provide a lot of resolution.
The truncation point k* can be estimated jointly while fitting the model and is flexible (we suggest truncating any columns of Λ defining modules that explain <1% of the phenotypic variation in any observed trait).
By defining modules and pathways and relating them to various diseases or trait of interest (endophenotypes [ 18, 19]), a better biological understanding of complex diseases and traits would be possible.
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This transformation is useful for defining module detection procedures.
The fact that NCL is a modular language allows the defined modules to be grouped into profiles.
In a later phase, the defined modules are implemented and the global design can evolve to be adapted to new technical requirements.
We defined modules enriched in dioxin-enabled, -sensitive, or mixture of both types.
We then look for biological relevance in these newly defined modules.
Our method compares well to the other 3 methods, however, at less defined modules it is not as accurate as the InfoMap method.
The selection of these recombination sites defines modules that consist of a core sequence (C, sequence variable among homologues) flanked by two 4 nt sequences (f).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com