We chose to adapt prior methods of epigenetic screening using 5-aza/TSA treatment that have been found to be successful in defining candidate tumor suppressor genes.
When possible, previous studies on gene expression in other conifers were also taken into account when defining candidate genes (Eveno et al. 2008).
Reduction of the QTL interval with large populations and dense marker maps for fine mapping is valuable in this context for better defining candidate genes underlying mapped loci.
Plausible biological hypotheses linked to neurotransmission and neurodevelopment in general and common to different psychiatric conditions need to be considered when defining candidate genes for ADHD association studies.
Minimum consensus approach - For our secondary species hypothesis (SSH, i.e., defining candidate species), we chose a conservative minimum consensus approach relying only on uncontradicted positive species identification based on the methods described above.
However, the plasticity of the molecular machinery involved in wood formation [ 3] may result in some difficulties in terms of defining candidate genes when expression patterns are compared over different annual growth periods.
Thus, these findings are important in defining candidate pathways potentially involved in vivo, but they do not necessarily represent actual signals induced upon Epo stimulation of primary human erythroid progenitors (PEPs).
Judging from the advertising volume, the two parties and outside groups seeking to influence close elections view the estate tax as something that can define candidates in the minds of voters.
Imaging of the small bowel has changed in recent years, but the imaging goals are primarily to determine the extent of small bowel involvement, assess complications and define candidates for surgery.
