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It is possible that differences in these and other biological markers in tumors that appear histologically similar are indications of the mutational history of the tumor and the pathway by which they arose, rather than defining a difference in tumor type.
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Based on the number of tissue samples and the resolution of the quantification method, we defined a difference in miRNA abundance by ±50% from Control, corresponding to ±0.58 on the log2RQ scale, as up- and down-regulation, respectively.
We defined a difference in hospitalization rates of more than 1000 days per 1000 inhabitants as clinically important.
For the scales of the QLQ-C30, this results in defining a difference of 5 – 10 points as a "small" difference, 10 – 20 points as a "moderate" difference and >20 points as a "large" difference.
Thus, the art historian Erwin Panofsky was attempting to define a difference of principle in the design of Romanesque and Gothic sculpture when he stated that the forms of Romanesque were conceived as projections from a plane outside themselves, while those of Gothic were conceived as being centred on an axis within themselves.
We defined a difference over time in problems during work as a decrease or increase of 2 points or more.
However, process robustness (defined as a difference in flow rate ratios) decreased strongly with increasing temperature to the extent that any significant increase in temperature over 32 °C will likely result in operating points that cannot be realized technically even with the lab-scale piston pump SMB system employed in this study.
Similarly, IDI is defined as a difference in discrimination slopes in these models.
The endpoint for the longitudinal phase of the study was defined as a difference in NSIs between the groups.
A clinically relevant difference in outcome was defined as a difference in total WOOS score of ≥ 10 points based on the opinion of the surgeons at our department.
Such differences could point to Gene × Environment (G×E) interaction, which is defined as a difference in the influence of genetic factors conditional on environmental exposure [ 12].
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CEO of Professional Science Editing for Scientists @ prosciediting.com