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The registry defines the date of surgery as day 0, however, this definition may have been interpreted differently by clinicians responsible for the collection of data.
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Furthermore, we defined the date of onset of migraine symptoms.
We will use this date to define the date that the diagnosis was performed.
We defined the date of hospital admission or emergency department visit as the index date.
For each gout patient, we defined the date of the first recorded gout diagnosis as the index date.
21 We defined the date of the first statin purchase as the cohort entry date for all individuals.
We defined the date of return of the questionnaire during 1991-92 as the start of follow-up.
To calculate refill nonadherence we first defined the date of the first prescription in 2001 as well as the end date of the last prescription initiated in 2001.
For each participant we defined the date of cohort entry (baseline) as the date of first biopsy identified in the database.
Rather, as noted previously, we had to define the date of CDI diagnosis based on the date the ICD-9 code 008.45 first appeared on insurance claims.
For cases with missing information on this item, we defined the date of death as 1 month after the date of the last medical visit.
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