I plan to implement robust functional studies to define the consequences of these genetic abnormalities and bridge them to the patient's clinical phenotype.
Who can be surprised if Brecht worked over an 18-year period on a work which seeks to define the consequences of that moment at which western man realises that the universe is not as he thought it was?
In this section we take up what is, in some sense, a more fundamental question regarding the status of the law of remedies as a whole: to what extent are the legal rules that define the consequences of contractual breach subject to modification or displacement by the contracting parties themselves?
As such, a large body of work has focused on defining the consequences of psychostimulant use on dopamine signaling in the striatum as it relates to addictive behaviors.
A significant development that facilitated the appreciation of the physiological importance of PTEN has been the generation of sophisticated animal models to define the consequences of the loss of function of this phosphatase [ 9].
Further studies are required to define the consequences of the inappropriate use of reporting recommendations in clinical and epidemiological research, in particular the use of these checklists as an instrument to assess the methodological quality of studies.
To molecularly define the consequences of BRDT inhibition by JQ1, we performed genome-wide expression analysis of males treated with 50 mg/kg JQ1 daily for 6 weeks (6 12 weeks of age).
To further define the consequences of astrocytes on GSCs, gene expression profiles were generated from NSC11 and GBAM1 cells grown alone (monoculture) and compared to those generated 48 h after the initiation of coculture with astrocytes.
Moreover, additional studies are needed to define the consequences of ABCD3 overexpression in AA prostate tumors; however due to the intrinsic role of ABCD3 in fatty acid beta oxidation, this would imply that ABCD3 could have a role in enhanced growth in both BPH and malignant cells.
Studies in this yeast have also defined the consequences of several mutations in isoform-1 of the ADP/ATP translocase [adenine nucleotide transporter isoform 1 (ANT1)] that have been associated with various diseases, including autosomal dominant PEO and hypertrophic cardiomyopathy (Kaukonen et al., 2000; Liu and Chen, 2013).
