The purposes of the present phase I/II trial were (1) to define tolerable doses of ixabepilone and sorafenib when used in combination and (2) to evaluate the efficacy and toxicity of this combination in the treatment of patients with human epidermal growth factor receptor-negative metastatic breast cancer (MBC).
Indeed, SIL requirements (cf. paragraph 2.2) are quantitatively defined using Tolerable Hazard Rate (THR) and, also, as mentioned above, no phases of operation can be distinguished in railway systems.
This study defined a tolerable dose of olaparib in combination with dacarbazine, but there were no responses in chemonaive melanoma patients, demonstrating no clinical advantage over single-agent dacarbazine at these doses.
Likewise, few can seriously object to its demand that banks hold enough liquid assets to withstand a severe, month-long liquidity shock.The tricky bits will be setting the absolute level of capital that is needed in the system and defining a tolerable amount of short-term funding.
It defines the tolerable level mentioned above.
The value of can be automatically generated by defining a tolerable capacity loss coefficient according to.
In fact, the urgency level depends on many factors: location, social distance (e.g., if it's a friend or an acquaintance), current activity, mood, etc. Radiator allows programmers to define the tolerable propagation delay of each message based on the current context of the users involved (sender and recipient).
After defining the tolerable dose of LCL-30 in vivo, we sought to identify the pharmacokinetic behaviour of this compound.
Critical effects used to define this Tolerable Daily Intake (TDI) were effects on the reproductive, developmental and endocrine systems.
