As usual in combinatorial topology, we consider a discretization of the space, and represent it by a graph G, where two vertices are defined to be close to each other if and only if they belong to the same edge (the corresponding points can be as close as desired, by considering a subdivision of the space as fine as needed).
Strikingly, both clusters contain solutions with the C-terminus of site 1 Ub at close proximity to the Josephin active site, even though no explicit distance restraints were defined to position a Ub close to the active site of Josephin.
Lagophthalmos is defined as the inability to close the eyelids [ 1].
Oil giant Shell became the last of the FTSE 100 companies to close its "defined benefit" final salary scheme last month and two out of three people in the private sector now fail to save at all.
Edwards's message to players was even more clearly defined: if they get back to close to.500 by the time they face Tennessee on Dec. 1, they will have a chance.
Tesco wants to close its defined benefit pension scheme - which guarantees a pension based on earnings and length of service - to new members and for existing members' future accrual.
Woods' preparation for Oak Hill is certainly physical in nature, but mentally I would place any bet that he's gone through shot-by-shot and hole-by-hole and clearly defined how he's going to close the deal.
But they also represent a loophole, which the Obama Administration tried to close, by defining "temporary" as no more than three months.
The binding site for virtual screening was defined closed to key residues Glu69, Pro71, Ile72, Leu74, Met75, Ala101, and Pro106.
And last month Rentokil, a services conglomerate, became the first member of the FTSE 100 index to say it wanted to close its defined-benefits plan to further accruals from members.
