The strategy producing the lowest mean cost is defined to be the optimal intervention.
Participants were defined to be at optimal care at their Look AHEAD baseline or 1-year visit if they met all three of the following criteria at the visit: 1) A1C <7%, 2) blood pressure <130/8 0mmHg, and 3) fasting LDL cholesterol <100 mg/dl (5).
The adaptive strategy to be implemented at that time step is defined to be the most frequently optimal strategy for the 100 posterior samples.
We define a policy Π∗ to be optimal if υ Π ∗ ≥ υ Π.
We define a policy τ∗ to be optimal if ζ τ ∗ ≥ ζ τ, for all τ.
Each putative (wild-type) network is assumed to be optimal, defining a chromosome missegregation rate of one.
Genetic predictors and endophenotypes might be defined to indicate optimal target selection (Weiss et al., 2012 b ).
An optimization problem is defined to find optimal sets of design variables which maximize buckling loads at constant weight/volume of the plate.
The ROC curve value closest to the upper left corner was defined to provide optimal sensitivity and specificity for each parameter.
To explain this more precisely, we define Sopt to be the optimal sequence under the original unchanged competition parameter values V and P V, Sopt) to be the corresponding profit of this sequence at those parameter values.
