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Among the patients who met inclusion criteria two groups were defined: the treated group who received DrotAA and the control group, which did not receive this therapy because of formal contraindication.
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For conventional radiotherapy schemes, a better delineation of the primary tumour will in general lead to smaller safety margins used in radiotherapy to define the treated volume.
The full set of results from our overall preferred specification are presented in Appendix C. Table 4 shows that the results we observed in Table 3 are not highly sensitive to the choice of which market structure index we use to define the treated groups.
25 26 Specifically, we defined the newly treated cohort as patients who started treatment in the 12 months before October 2003 (six months before pay for performance) and followed them for up to 45 months until July 2007.
A minimum of 1 3 of the time (206 days) covered by at least 0.25 μg of alfacalcidol, 1 3 of the time (206 days) covered by a mean of ½ DDD of RAS inhibitor or at least 16% of the time (100 days) covered with a mean of one DDD of NSAID defined the patients treated.
Angiographic restenosis was defined when the treated vessel developed a blockage with more than 50% diameter compared to the reference diameter proximal to the occlusion.
Before applying each formulation, a circular region, 24 mm in diameter, was defined on the treated area using a polyethylene adhesive template fixed to the arm.
With the CT-scan simulator (Picker PQ 2000 + ACQSIM), GTV, CTV, and PTV were determined as defined above, the treated volume and the irradiated volume according to the ICRU report 50 [ 7].
Diabetes was defined by the treating physician.
Bedside nurses maintained the mean arterial pressure (MAP) at the target range, defined by the treating physician (70 80 mmHg) by adjusting the dose of norepinephrine infusion.
The target volume of the intraoperative boost includes the tumor bed or the high risk region for positive or close margins as defined by the treating surgeon and the radiation oncologist together if the complete tumor bed cannot be covered.
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