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While the PPARγ role in tumour growth has not been clearly defined, the involvement of the altered polyamine metabolism in colorectal carcinogenesis has been established.
Here, we defined the involvement of a molecular switch, p38, in apoptosis and autophagy in selenite-treated human leukemia NB4 cells, schematically summarized in Figure 8f.
In the context of our interest on primary care based case management we defined the involvement of a primary care physician (either general internist, general practitioner, family physician) in planning the management of individual cases as being essential.
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Herein we define the involvement of PI3Ks in orthopoxvirus morphogenesis using PI3K inhibitors and cell lines deficient in the regulatory subunit of Type I PI3Ks, p85.
Therefore, we define the involvement of MST2, but not MST1, as a regulator of photoreceptor cell death after RD.
Therefore, more studies are required to define the involvement of the gut chemosensory system in colonic ion transport.
To define the involvement of Perp here, we analyzed Perp expression and localization throughout the different stages of mammary gland morphogenesis.
Additionally, clinical and tumour phenotypic variables have been taken into account to better define the involvement of VDR in these pathologies.
To define the involvement of the putative miRNA-574-5p miRNA-574-5p miRNA-574-5pdegradatargetthe 3′UTR sequences oforerS1-2 with or without the mRNAA-574-5p target sequence were sub-clonedegradationam of the full-length luciferase cDNA, whose expression was constitutively activated by the CMV promoter (Fig 7A–C).
However, because of the species concept in bacteria (see e.g., Doolittle and Papke 2006), the analysis of other taxa is needed to more precisely define the involvement of chromids in strains differentiation in relationship with different taxonomic levels (e.g., species and genus).
This study defines the involvement of CB2-mediated signalling in the in vivo and in vitro growth inhibition of prostate cancer cells and suggests that CB2 agonists have potential therapeutic interest and deserve to be explored in the management of prostate cancer.
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