No significant deviations from expected fever rates amongst P. falciparum only and mixed-species infections were seen when clinical malaria was defined more stringently as temperature ≥37.5°C or 38.0°C along with a positive microscopy reading or along with parasite density ≥1000 parasites/µl (data not shown).
Only when clinical malaria was defined more stringently as temperature ≥37.5°C along with parasite density ≥5000 parasites/µl, was there a negative association of mixed infections with clinical malaria, and this was seen in children only (OR 0.43 (95% CI 0.19 0.96) p = 0.035).
Coercion, defined more stringently as 'forced sex', of Thai males by same-sex partners has been explored by Guadamuz et al. (2011).
The same associations between HPV loads and persistence were obtained when HPV persistence was defined more stringently by using three consecutive HPV-positive visits for the same type.
Studies of microbial diversity in the ocean have also used phylotypes that are defined more stringently, with 100% identity, and found that rare organisms are more useful for clustering members from similar communities than more abundant phyla, although they found that this was true both for the 100%-ID phylotypes and a less stringent ~94%-phylotype [ 26].
The C-terminal DAD motif usually found in GBD/FH3-containing formins is defined very stringently in the Pfam database, as it detects only a subset of proteins reported to contain it (namely formins of the Diaphanous subfamily) and misses, e.g., all yeast and Dictyostelium formins, as well as some mammalian ones.
To our surprise, none of our stringently defined coding fRNAs overlap with predictions from the most stringently defined set of coding fRNAs in Steigele et al. [4].
The major tool of structuralist psychology was introspection (a careful set of observations made under controlled conditions by trained observers using a stringently defined descriptive vocabulary).
Unexpectedly, of 97 stringently defined, T cell-specific transcripts with unknown functions that we identify, none encode proteins with the modular architecture characteristic of 80% of leukocyte surface antigens.
