(vi) In any nonattainment area for PM2.5 in which a state must regulate Ammonia as a regulated NSR pollutant (as a PM2.5 precursor) as defined in paragraph II.A.31 of this Ruling, the reviewing authority shall define "significant" for Ammonia for that area and establish a record to document its supporting basis.
Since paired normal of these cell lines cannot be obtained, we defined significant change in expression for those genes whose expression is higher (>60 %) or lower (<40 %) than the median expression as suggested in [ 34].
The authors defined significant growth defect with correction for multiple comparisons by controlling the false discovery rate to 0.1.
In recent years, factorial designs - which are statistical techniques for designing experiments, defined significant effects, building models, evaluating the effects of variables and searching for optimum conditions - have successfully been used to optimize many bioprocesses [ 22, 23]; however, they are not yet the most common strategies used to evaluate heterologous protein expression.
To determine whether low or decreasing protein C places patients at a high risk of mortality, analyses adjusting for six previously defined significant risk factors (APACHE II score, age, log IL-6, presence of comorbidities, presence of dependencies, and urosepsis) [ 15] were performed on data from PROWESS placebo patients (Table 2).
Abiomed has not defined significant changes.
p<0.05 was defined significant.
We reconstructed the gene network of the initial dataset, defining significant similarity for sequences with a BLAST e-value < 1e-5 and >30 % identity, inferred as the BLAST identity multiplied by hit coverage for the shortest sequence, as in [ 47].
Finally, the criteria used in this study for defining significant progression of LS was chosen after performing different exploratory sensitivity analyses looking for that with the best performance, as there are not enough studies so far that have established a "consensus definition".
Heterogeneous patterns of proto-oncogene activation have been noted, and traditional approaches such as determining average fold differences, t-tests, and other techniques may fail to define significant alterations in expression for specific genes in high-throughput array approaches [14].
