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The surrounding sequences of many proteasome phosphosites conform to well defined recognition motifs of kinases, such as S/TP (MAPKs and CDKs), R/KxxS/T (AGC and CaMK families), S/TxxD/E (CK1 and CK2), and S/TxxxS/T (GSK3).
Although REases usually cleave specific DNA sequences accurately, certain REases cleave sequences which are similar, but not identical, to their defined recognition sequences under non-optimal conditions, such as the presence of organic solvent, sub-optimal pH values and high enzyme concentrations.
Both DNA methylation and cleavage occur within or close to a defined recognition site.
We defined recognition of substantial excess weight as self-identification as either 'very overweight' or 'obese' (table 2).
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We define recognition to be a hit with E < 0.005, the default threshold, and with the pairwise alignment fulfilling the following two criteria: proper alignment of the F8 His residues and of helices BC through G.
More generally, similar coding problems may occur in other recognition problems in biology, such as protein-RNA recognition and protein-protein interactions through defined protein recognition motifs [ 62, 63].
The coiled coil environment has the great advantage to provide two very well defined intermolecular recognition surfaces.
The New Mainstream is defined by recognition that we are in a time of awakening to a new mindset, an expanded worldview and yes, a higher-level consciousness for humanity.
Multiple checkpoint mechanisms have been defined for recognition and repair of DNA damage during interphase (e.g. G1/S and intra-S phase checkpoints) and chromosome dynamics during mitosis (e.g. spindle checkpoints) [2], [3], [4].
We defined late recognition to estimate severity of AKI when this time interval to reach 50% relative increase between the crude and adjusted sCr exceeded 24 hours.
The eligibility criterion for steroid resistance or intolerance is defined in recognition of a reluctance of nephrologists to routinely administer a prescribed course of corticosteroids to all patients because of the potential for serious adverse events.
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