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Most proteins fold into their native structure through defined pathways which involve a limited number of transient intermediates.
One application that desires these qualities is metabolon construction wherein multiple enzymes are organized in defined pathways to mediate biochemical flux.
Resistance and safety issues have been circumvented by some of these new agents that have well-established mechanisms of action and defined pathways leading toward regulatory approval.
We introduce an integrative hierarchical analysis of tumor progression that discovers which a priori defined pathways are relevant either throughout or in particular steps of progression.
A third characteristic of preparation for the workplace today is the need for clearly defined pathways.
As noted by Lois M. Davis of Rand Corporation, successful reentry from a public health perspective requires clearly defined pathways to integrated health care and a variety of socio-economic services, including educational/vocational programs and supports.
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A total of 1,695 pre-defined pathways were screened with the 324 genes using gene set enrichment analysis [ 41].
The lower number of knowledge constraints may reflect the scale of our analysis (which focused on decision points in pre-defined pathways); new knowledge and participatory approaches would likely yield a richer set of scenarios.
To achieve flexible energy storage devices with high performance, a new class of flexible electrodes with exquisite architectures that provide well-defined pathways for efficient ionic and electronic transport is highly needed.
One popular approach has been to compare the identities of the differentially expressed probes to databases of pre-defined pathways.
While these approaches are appealing for their interpretability, they rely on the appropriately pre-defined pathways rather than the structure of the data under study.
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