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The solution of the defined optimal control problem is obtained by applying the direct collocation method.
A visually defined optimal threshold value was set for each tooth in the YZ (sagittal) plane (Figure 1).
Here, we evaluate the performance of empirically defined optimal thresholds (1) in the sample in which they were defined and (2) in the population from which the sample was drawn.
For some of the parameters we even found the same well defined optimal values as with the initial smaller ranges (see figure S5).
Very recently, we defined optimal 'windows' of gestation of human and pig embryonic precursor tissues that afford optimal growth and development of liver, pancreas and spleen upon implantation into NOD-SCID mice[8].
For our initial studies we added 1 µM ATRA or our previously defined optimal concentration of rapamycin (100nM) to purified CD4+, CD25+, CD127dim Tregs, activated them using KT64.86 cells loaded with anti-CD3 Abs, and monitored cell expansion for 15 days.
Similar(24)
Many diagnostic studies are aimed at defining "optimal" thresholds.
Currently, little evidence is available to define optimal nonsurgical management.
Stability analysis is fundamental for defining optimal aircraft architecture.
Defining optimal strategies and showing that they are optimal is generally considerably more difficult than simply defining a strategy.
To define optimal regimens, we systematically reviewed combination chemotherapy trials (N = 83).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com