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A defined modification of the physical model verified the simulation model.
Our findings open novel technically challenging avenues of research requiring the production and extensive functional analysis of PABP1 of defined modification status.
In addition, the antibody should bind the modified amino acid residue only at defined modification sites on the target protein, which implies that not only the modification but also the amino acid sequence must be recognized.
We have modified this paragraph to make the point clearer and better reflect what the reviewer was asking for: "Moreover, the antibody should bind the modified amino acid residue only at defined modification sites on the target protein, which implies that not only the modification but also the amino acid sequence must be recognized.
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To investigate the significance of protein changes under disease conditions, we have chosen a more systematic and simplified approach by using mouse embryonic stem (ES) cells with highly defined modifications in a controlled environment.
Synthetic peptides carrying defined modifications have played important roles in a large number of studies, from use as substrates in enzyme assays to identification of protein−protein interactions.
Thus, higher plants have the ability to adapt to periods of stress by employing specific responses underpinned by defined modifications of their cellular processes.
From 1885, when the first human rabies vaccination occurred, to 1994, when the RV Street Alabama-Dufferin (Street Alabama-Dufferinineered with reverSADgenetics (29 ), methods for RAB19manipulation have changed fundamentally from random attenuation to defined modificationstrain
Our analysis has revealed for the first time evidence of defined modifications in the brain microstructure and neuroconnectivity, in co-occurrence with synaptic efficacy alterations, in a murine model of chronic T. gondii infection.
The relative contribution of the O-antigen and Lipid A to PAMAM-DG's bioactivity was determined by constructing genetically engineered strains of S. flexneri that express structurally defined modifications of LPS; gtrA has shorter O-chains and waaL expresses an endotoxin component of LPS that binds only to MD-2 (Molinaro et al, 2008; Rallabhandi et al, 2008; West et al, 2005).
This concept consists of defining modification domains, then defining global and several local modification functions in each domain.
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