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The primary parameter of interest was LV dysfunction (LVEF <40%, defined as mildly reduced LV systolic function where inotropic support should be considered) [ 14, 27] between 4 and 14 days after the onset of SAH.
All lesions are initially evaluated with B-mode imaging: they are defined as highly, mildly hyper-, iso-, and hypoechoic compared to normal brain parenchyma.
A focal, ill-defined mildly inhomogenous extradural mass lesion was detected by MRI.
US examination showed a 29 × 19 × 13-mm lobulated but well-defined, mildly hypoechoic nodule with a slight increase in through-transmission. Bilateral, digital, diagnostic mammography showed heterogeneous, dense, nodular parenchyma in both breasts.
For descriptive purposes of occurrence of food insecurity, the categorisation of food insecurity followed the HFIAS guide and was defined as food secure, mildly food insecure, moderately food insecure and severely food insecure, based on a number of assumptions that were made by the HFIAS authors, given there is no universally accepted approach to defining the cut-offs [ 24].
Consequently, in the present study, patients with mean lateral strain ≤ -20% were defined as having normal or mildly reduced RV function, while those with strain > -20% were defined as having reduced RV function.
The primary outcomes of our study were 1) mildly reduced eGFR, defined as eGFRcys < 75 mL/min/1.73 m, as this threshold is associated with higher risk of ESRD, death and cardiovascular disease [ 25], and 2) high urinary albumin to creatinine ratio (ACR), defined as ACR ≥ 17 mg/g in men and ≥ 25 mg/g in women [ 29].
eGFR groups were defined as normal (≥ 90 mL/mildly73 m), mildecreasedased (60 89 mL/min/1.73 m), moderately decreased (30 59 mL/min/1.73 m) or severely decreased (< 30 mL/min/1.73 m).
There was a high prevalence (54%) of frailty, as defined by CFS scores of 5 to 9 (mildly frail-terminally ill) [ 34], among this cohort of community dwellers.
Mild tubule‒interstitial damage is defined as tubular and interstitial lesions absent or very mildly focal (score < 2); severe is defined as focal or diffuse tubular and interstitial lesions (score ≥ 2).
Ki-67 proliferation index ≥10% was defined as Ki-67 positive by immunohistochemistry (<10% as negative; 10 19% as mildly positive, 20 29% as moderately positive, and >30% as strongly positive).
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