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All 90% CIs for the ratios were within the predetermined range of 0.8 to 1.25, which defined lack of interaction.
We defined lack of inferiority of total hip replacement as being within 5% of the revision surgery rate of hemiarthroplasty at 2 years.
We conservatively defined lack of calibration as chi-square values greater than 23.2 (the 99th percentile of chi-square distribution with 10 degrees of freedom).
As expected, in studies that defined lack of a smooth outline or halo as irregular margin, this parameter had lower positive predictive value (30%) and higher sensitivity (77.5%).
One study defined lack of medicine access when the person needed but did not use the medicine in the last 15 days, regardless of medical prescription [ 11].
For lung cancer, we defined lack of follow-up as failure to initiate further investigation or an appropriate action within 7 days of a documented 'red flag' such as an abnormal chest X-ray.
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This falls within protocol-defined lack of interaction bounds of 70%143%%.
This view was later entrenched by psychiatrists who defined a lack of orgasm during intercourse in women as a disorder.
Nonunion was defined as lack of bone healing at least 6 months after the fracture [3].
Non-union after femoral neck fracture is defined as lack of radiographic evidence of union 6 months after fracture.
At least one-third of patients with major depressive disorder (MDD) have treatment-resistant depression (TRD), defined as lack of response to two or more adequate antidepressant trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com