There were no selection criteria for RPFNA sampling except that the volunteer present a clinically defined increased risk of breast cancer.
The rubbery plateau modulus (EN°) was well defined increasing in the order of no diluent < TPGDA < TMPTA However, EN° was not defined with NVP.
The value 0 is term birth (according to the current documentary of the registry this means gestational age ≥ 40 weeks), and the values 1 8 define increasing degrees of prematurity (table 1) [15].
Fluid responsiveness was defined as increase of stroke volume (SV) >15 % after fluid challenge measured by PAC.
And aging is defined as increase of accidence of death with age.
Fibrosis was defined as increase of collagen and fibroblasts in the endomysium.
The relapse rate (defined as increase of CDAI >70 over baseline and CDAI ≥150) was not significantly lowered.
For this exercise, we chose 1 min increments to evaluate the curve and defined an increase of > 30 mV/minute as a significant increase (Additional file 1).
We defined an increase of 20% during NT as significant in concordance to previous reports in metastatic breast cancer (Lipton et al, 2011).
We defined IOP increase of 4 mmHg as a cutoff point because the mean diurnal fluctuation is 3.7 mmHg in normal eyes without glaucoma [ 13].
