RD was defined in 3 ways: (1) >25% reduction in creatinine clearance, (2) >50% increase in serum creatinine, and (3) >50% increase in serum creatinine with an abnormal peak serum creatinine (>1.3 mg/dL for men and >1.0 mg/dL for women).
Laboratory-confirmed pandemic (H1N1) 2009 infection was defined in 3 ways: 1) isolation of influenza A virus, followed by positive RT-PCR result for pandemic (H1N1) 2009 virus; 2) positive rapid influenza A test result, followed by positive RT-PCR result for pandemic (H1N1) 2009 virus; or 3) pandemic (H1N1) 2009 virus HI titer >40.
Prodromal fever were defined in 2 different ways: patients reporting a measured fever ≥ 37.5°C during prodromal period; any fever (measured or subjective) during prodromal period [ 21, 22].
In this mapping system, the same coordinate can be defined in 2 different ways: by either choosing the smaller unit and adding the subunits or choosing the greater unit and reducing it by the subunits.
We investigated whether metabolic syndrome, defined in 3 different ways (2 commonly used and 1 novel) is associated with arterial alterations in obese children.
Active TB was defined in 3 different ways.
To increase the diagnostic accuracy and reduce bias, asthma was defined in two ways: (1) definition 1: ICD-10 code J45 or J46 that was repeated with at least a 1 month interval; and (2) definition 2: definition 1 plus use of any asthma medication at least once.
Early responders were defined as clinical responses at week 12; later responders as responses at week 24, but not week 12. Responses were defined in two ways: ACR20 response (as defined in the protocol) or decrease from baseline in DAS28 ESR) ≥1.2.
Known-groups validity was examined to determine whether the UC-PRO/SS could distinguish between patients by disease severity, defined in three ways: 1) by Partial Mayo Scores (mild, score 0 4; moderate, score 5 7, severe, score ≥ 8); 2) by clinician-rated global assessment of disease severity; and 3) by patient-rated disease severity.
Treatment intensification (IT) was defined in two ways: (1) adding a second OAD (OAD2) or (2) adding insulin to the first OAD (OAD + INS).
