Exact(17)
Meanwhile, we defined differentially regulated link (DRL) by combining differential regulation, differential expression and the regulation contribution of the regulator to the target.
Of the 103 defined differentially expressed peptides, 65% (67 markers) could be confirmed as also being significantly different in the 'Rossing' cohort between diabetic patients with DN and diabetes controls.
Of the 65 previously defined differentially expressed peptides [1], in the current study 92.3% (60 markers) could be confirmed as being significantly different in this PREDICTIONS cohort between diabetic patients with DN and diabetic controls at p<0.05 and 50/60 were significant at p<0.0001.
As an alternative analysis, we defined differentially expressed genes as those with a 1.5-fold change in expression, i.e., expression values were averaged across the lateral axis in each class, and then the ratio of the averages of the two classes was calculated.
We defined differentially expressed genes at each transition and subsequently detected functional modules.
We defined "differentially sensitive sites" (DSSs) as those 150-bp regions present in either one of the two cell types.
Similar(43)
We defined differentially-expressed genes by calculating P values between any two libraries using a previously reported statistic method [ 28]; the process yielded 1,751 (8.5%) and 1,216 (5.9%) significant differentially-expressed genes with P values of < 0.05 and < 0.01, respectively (Table 4).
Typical individual-gene analyses (Khatri and Draghici, 2005; Rivals et al., 2007) employ a cutoff threshold to define differentially expressed genes (DEGs) and then search for the biologically pre-defined gene sets that are enriched with the DEGs.
Another factor strongly affecting the final results of microarray data analysis is the method used to define differentially expressed genes.
To define differentially expressed transcripts between wide type and heat shock conditions, SAM (significant analysis of microarray, siggenes package from BioConductor) was employed to compute the q value.
Correlations of transcription factors were performed by defining differentially expressed genes at FDR<1% in breast cancer prognosis measured with metastasis events within 5 years [12], which correspond to 179 microarray probes, or by defining differentially expressed genes at FDR<5% in docetaxel treatment response [37], which correspond to 1,525 probes.
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