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The method makes use of a sine-wave ridged pattern commonly found in nature which produces a compliant bending pattern along various directions defined by the reference axes.
In relation to applicability, all included studies scored well for the reference standard domain except one [35], since the target condition as defined by the reference standard (SEIMC) which was used for definition of bacteremia does not match the review question.
We calculated the coordinates of each hybrid zone specimen on the discriminant axis defined by the reference populations (figure 2).
The first type of constraint requires that the food mixture contains at least the IAA content defined by the reference pattern.
The reference vector, which initially points along the x-axis, was iteratively shifted by 9 degrees (the da parameter) counterclockwise until it was shifted to the next orientation class as defined by the reference vector's initial direction.
Applicability: Are there concerns that the target condition as defined by the reference standard does not match the question?
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In such case, the initial candidate position is defined as the mean computed among the coordinates defined by the intersection of the line defined by the references with the parallel lines [19].
Interestingly, the 3D pattern denoted by the virtual reference Atom2088 (4QIP) was located in the SDS binding site whereas the 3D pattern defined by the virtual reference Atom1043 (3U90) was located in an extracellular zone of the protein (Fig. 10).
The atmospheric profiles defined by the Venus International Reference Atmosphere (VIRA) (Seiff et al. 1985) are assumed in all simulations.
These 3D patterns, defined by the virtual reference Atom1393 (in MAO-A) and Atom12422 (in SERT), have a GScore value of 100%% (Fig. 11).
After an evaluation with the software MetaPocket [56], a possible ligand-binding site was identified in the same zone that was defined by the virtual reference Atom1043 in the protein 3U90 (residues ALA14 and ALA15; Additional file 1: Figure S2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com