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Organ dysfunction and organ failure were defined by a Sequential Organ Failure Assessment (SOFA) score for the appropriate function above one and above two, respectively [ 9].
The multicentre European Sepsis Occurrence in Acutely Ill Patients (SOAP) study found that 51% of septic patients developed AKI, defined by a Sequential Organ Failure Assessment score above 2 (serum creatinine >177 μmol/l) [ 17].
Based on this hypothesis our a priori stated study question was: in a population of ICU patients who receive positive pressure respiratory support (invasive or non-invasive) in the absence of non-respiratory organ failure, what is the 14-day incidence of and baseline risk factors for AOF (defined by a sequential organ failure assessment (SOFA) score ≥ 3) [ 16]?
*Organ failure free days, organ dysfunction free days, and vasoactive drug free days are calculated at day 14; Organ dysfunction was defined by a sequential organ failure assessment (SOFA) score above one for the appropriate function; Organ failure was defined by a SOFA score above two for the appropriate function.
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In ICU patients, survival of patients with or without neurologic events was not different, whereas there were more deaths in patients with neurologic failure defined by a neurologic Sequential Organ Failure Assessment score >2 [13], which corresponds to a Glasgow Coma score <10 [45].
Liver dysfunction at baseline was defined by a liver Sequential Organ Function Assessment (SOFA) score >0.
In this study, patients were compared by whether they developed AKI, defined by a renal Sequential Organ Failure Assessment score of 2 or greater, or by urine output under 500 ml/day.
In ICU patients, survival of patients with or without neurologic events was not different, whereas there were more deaths in patients with neurologic failure defined by a neurologic Sequential Organ Failure Assessment score >2 [ 13], which corresponds to a Glasgow Coma score <10 [ 45].
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CSD was defined by the sequential onset in adjacent channels of a propagating slow potential change (SPC) (Fabricius et al., 2006).
Spreading depolarization was defined by the sequential onset in adjacent electrodes of a propagating, polyphasic slow potential change (Figs 1A and 2A) (Dreier et al., 2006; Fabricius et al., 2006).
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