Triangulation arrangement is fairly straightforward for sectors among which relative degrees of fabrication are clearly defined based on expert knowledge of industrial technologies.
The negative class of this dataset was defined based on literature knowledge of treatment effects in humans and rodents.
The ranges for these categories were defined based on the knowledge that frizzled receptors (Fzd 1 10) are expressed in mouse as well as in human ES cells [27].
The multi-SNP analysis aims to test association based on a SNP set, usually defined based on biological knowledge such as gene or pathway, which may contain only a portion of SNPs with effects on the disease.
Therefore, we analyzed the microarray data using Gene Set Enrichment Analysis (GSEA) [ 33] to identify gene sets defined based on prior biological knowledge, such as the Gene Ontology category.
However, most of these data cannot be precisely defined based on pre-existing knowledge, as they incorporate both definite and vague components.
Gene Set Enrichment Analysis (GSEA) [ 29], was used to find whether a set of genes defined based on prior biological knowledge (e.g., those in a common signaling pathway) shows statistically significant correlations with IL6.
This strategy is very similar to what has been performed for analysis of multiple genes using gene arrays: although it is possible to set up arrays using very large numbers of gene, it is also possible to use gene sets containing smaller numbers of genes that are defined based on prior biological knowledge, for example, published information about biochemical pathways [ 44].
Unfamiliarity with other fields: a search string was defined based on experience and authors' knowledge, but we cannot completely avoid the possibility that some terms defined in the search string have synonyms that we have not identified. .
Unfamiliarity with other fields: a search string was defined based on experience and authors' knowledge, but we cannot completely avoid the possibility that some terms defined in the search string have synonyms that we have not identified.
