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Disease relapse was defined as vital organ-threatening vasculitis activity, such as, disease of the eyes, lungs, kidneys, or sub-glottis, or other manifestations attributable to active vasculitis necessitating escalation of immunosuppression.
We examined the association of StO2 parameters in relation to three patient-oriented outcomes: (1) presence of shock, as defined above, assessed at the time of enrollment; (2) in-hospital mortality, defined as vital signs status at hospital discharge; and (3) organ dysfunction at 24 hours assessed on the basis of the SOFA scores calculated at the time of enrollment and 24 hours later [ 6].
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A critical P-AE was defined as a vital sign or arterial blood gas analysis parameter with more severe abnormality detected (category 2 or worse), as well as other life-threatening events such as airway obstruction, accidental extubation, cardiac arrest, malignant arrhythmias, and others.
We excluded patients with significant pulmonary dysfunction defined as forced vital capacity (FVC) and total lung capacity values <60%% predicted and/or the forced expiratory volume in one second to vital capacity ratio (FEV1/VC) <70%% predicted.
Pathological complete response was defined as no vital tumor in breast or axilla (pCR, i.e. ypT0 ypN0) determined at surgery following the completion of chemotherapy.
However, the pathological response rate (defined as <10% vital cells in our study) was lower than in many other series [ 22, 48, 50].
Since aging is defined as degeneration of vital organs, and reproductive aging in C. elegans by diminished progeny production [21], we suggest that silica-NPs induce reproductive senescence in these nematodes that is due to degenerative changes in reproductive systems.
Restriction was defined as a forced vital capacity < 80% of predicted in the absence of concomitant obstructive abnormality.
Although at least minor tumor shrinkage was observed in the majority of patients, according to RECIST criteria most patients showed stable disease on imaging and poor response (defined as > 10% vital tumor) according to the pathological specimen.
Vital capacity (VC) was defined as the best value of forced vital capacity (FVC) and slow vital capacity (SVC).
Vital capacity (VC) was defined as the highest value of forced vital capacity (FVC) and slow vital capacity (SVC) pre- or post- reversibility test.
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