States for the gene expression nodes were defined as up-regulation, down-regulation and unchanged expression, using a 2-fold threshold to convert microarray readouts to discrete values.
A core regulation is defined as a regulation network which is identical within a subgroup of samples and represents at least T% of the total number of samples (step 4 Figure 1).
Working conditions were observed based on action regulation theory and defined as (1) regulation requirements, a workplace resource providing opportunity for decision-making and skill development and (2) barriers for task completion.
Perhaps the most important distinction in this respect is that between government intervention labeled as a "market access restriction" and that defined as "domestic regulation". Both the GATT and the GATS declare market access restrictions (such as import quotas or limitations on the number of service suppliers) to be, in principle, prohibited.
Here too, the PBi promoter in most of the LoxP parent cell lines that exhibited what we defined as tight regulation also had a very low activity in the presence of Dox.
Regime 1 (REG1) was defined as having both regulations in place (R14 = 1, R25 = 1).
For example, given a regulation where gene A activates the expression of gene B, the regulation is defined as a sample-specific regulation for the particular sample and is included in the sample-specific regulation network if both genes A and B are over-expressed or under-expressed in the particular sample.
Three discrete functional states were defined as 1) up-regulation (u, by ≥ 2 fold and FDR ≤ 0.05), 2) down-regulation (d, by ≥ 2 fold and FDR ≤ 0.05), and 3) no-regulation (n).
Second, we examine the epigenetic regulatory effect for every gene, here defined as the chromatin regulation effect; CRE of a gene is a measure of the mean absolute change of the gene's expression level when chromatin regulators are mutated, as was done previously [13].
The study design was a cohort study and the outcome was defined as abnormal glucose regulation.
