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Moreover, recent studies showing that many of the findings that were previously defined as pathology also appear in healthy children have altered the whole perception of the accuracy of the MRI features included in previous scoring systems and the main challenge we now face is how to differentiate normal findings from disease.
Serious pathology is defined as pathology requiring treatment.
Definite MI is defined as pathology findings of an acute MI within 28 days of death, or a rise/fall in cardiac biomarkers and/or objective indicative ECG changes, and preferably the presence of symptoms or signs (e.g. cardiac pain, cardiogenic shock).
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In this document, incidental findings are described as "findings that are unrelated to the clinical indication for the imaging examination performed" and include a specific category of "emergency findings" defined as pathologies which alter patient management before their next outpatient appointment.
For this purpose pathology is narrowly defined as pathological processes that cause gross or microscopic structural change in any of the body's tissues, including the brain, resulting in abnormality of function.
The proximate cause of death was defined as the pathology leading to the death of the patients or the decision to withhold or withdraw intensive care.
Results of fundus examination was classified as: 1) retinopathy defined as vascular pathology as a result of diabetes, hypertension or other conditions [ 12, 13].
An inconclusive diagnosis was defined as no pathologies visible or as an unclear lesion visible, which both needed further investigation.
In the VITA study, where mixed pathologies were defined as any other pathologies, including also less regarded pathologies such as HS and TDP-43 proteinopathy, and non-AD tauopathies, the prevalence of mixed pathologies was over 70% [ 5].
Cause of death was defined as the primary pathology (irrespective of its duration) leading to death of the patient or to the decision to withhold or withdraw intensive care therapy.
**** Not Malignancy or Not An Incident Malignancy defined as records confirming pathology were benign or date of diagnosis prior to enrollment in CORRONA A comparison of the predictive value of the CORRONA questionnaire and the adverse event form to the gold standard of medical records review is shown in Table 4.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com