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For GSE22220 dataset low and high grades were defined as grade 1 and 3, respectively.
Mast is defined as Grade A equipment which is essential for the safety and continued combat capability of the ship.
It may be accompanied by a mild increase in reticulin fibers defined as grade 0 or 1 on a scale of 0 to 3 according to the European Consensus7.
Dose-limiting toxicities (DLTs) were defined as grade 3 4 leukopenia, thrombocytopenia, anemia, fever with grade 4 neutropenia and more than grade 2 non-hematologic toxicity, with the exception of nausea, vomiting, and alopecia.
Serious toxicity is defined as grade III/IV nonhematological toxicity or major hematological toxicity.
The presence of WMLs was defined as Grade 2 or greater in this study.
RILD was defined as Grade 3 or 4 hepatic toxicity according to the Common Toxicity Criteria of the National Cancer Institute.
Notably the independent prognostic value of the profile held true regardless of whether low grade was defined as grade 1 or grade 1 and 2 disease (Table 3).
Temperature was measured with an oral thermometer; fever intensity was defined as grade 1 37.5°CC to 38°C), grade 2 >38°CC to 39°C) or grade 3 >39°CC).
Significant toxicity in chemotherapy trials is usually defined as grade ⩾3.
An event is defined as grade 3 or grade 4 toxicity, objective tumour recurrence, or death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com