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Switching therapy was defined as dispensing an osteoporotic drug other than the index drug while not obtaining a refill of the index prescription within 45 days after the last supply day of the previous dispensing at any time during the follow-up period.
Second-line therapy with nab-paclitaxel was defined as dispensing of nab-paclitaxel as part of second-line therapy, defined as additional treatment different from the first-line therapy and initiated ≥ 30 days after the first chemotherapy or after a large gap (eg, 90 days) in therapy.
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Therapy initiation was defined as a dispensing for an oral antidiabetic agent preceded by 6 months in which no antidiabetic agent was dispensed.
First-line therapy with nab-paclitaxel was defined as initial dispensing of nab-paclitaxel as the first chemotherapy received after a diagnosis of metastatic disease.
Annual prevalence was defined as the dispensing of 1 or more prescriptions for a psychotropic drug during the study year (2000) per 100 enrolled youth.
Initiation of ACEI was defined as the dispensing of an outpatient prescription for an ACEI with no previous record of ACEI use in the past 6 months.
Our analysis focused on new users of therapy, which was defined as no dispensing of a ULD in the prior 6 months.
Veterans receiving palliative care in the 6 months prior to the study were excluded; this was defined as any dispensing of palliative care medicines subsidized under the Australian Pharmaceutical Benefit Scheme or a palliative care service claim under the Australian Medicare Benefits Scheme.
Follow-up time started on the index date, defined as the dispensing date of the first study drug, and ended at the first of any of the following censoring events: discontinuation or switching of study drugs, loss of health plan eligibility, end of study database, or death.
Stopping therapy was defined as failure to dispense any osteoporotic drug within 45 days after the last supply day of the previous dispensing at any time during the follow-up period.
Covariates included age at entry, gender, residential status (community dwelling or age-care resident), having used an endocrinology service, number of hospitalisation episodes (between the index diabetes prescription and therapeutic progression or end of the study), and adherence to diabetes medicines (defined as sufficient medicine dispensed to cover 80% to 120% of the treatment duration).
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CEO of Professional Science Editing for Scientists @ prosciediting.com