It is defined as, where j' corresponds to perturbations with s ij = 0, is the final cell mass after the j'th perturbation of parameter, and is the final cell mass using the default parameter set (16).
The strength of connection between a pair of tissues with regard to gene expression is defined as, where i and j correspond to probesets in tissue 1 and tissue 2, and N 1 and N 2 are the number of probesets in tissue 1 and tissue 2, respectively.
The first, defined as hypermethylated, corresponds to a CpG island at the 5′-end of the tetratricopeptide repeat domain 40 (TTC40) gene, whereas the second, defined as hypo-methylated, is located on repetitive sequences at chromosomes 16p11.1 and 13.1.
Geometric random graphs ("GEO") are defined as follows: nodes correspond to uniformly randomly distributed points in a metric space and edges are created between pairs of nodes if the corresponding points are close enough in the metric space according to some distance norm.
An empirical FDR for the Fourier score at a chosen threshold t was defined as: Hereby corresponds M to the number of permutations which were used for the null hypothesis.
Only a few of these structures defined as such correspond, in fact, to real GC.
The educational level of parents is defined as follows: "low" corresponds to education up to vocational school; "medium" indicates a polytechnic degree and "high" a university degree.
A pBVAS >0 was defined to correspond to partial remission.
Sensitivity is defined as #TP/ TP+ FN), which corresponds to recall, and specificity is defined as #TN/(#FP+ TN), which corresponds to precision.
Primers were designed for CpG sites −60 to +14 (corresponding to nucleotide numbers from −2314 to +137 bp) in which the first CpG site was defined as +1 which corresponded to RASSF1A transcriptional start site.
