Technically speaking, CONJ entries are defined as connected sub-graphs consisting only of bonds where each of the two atoms has at least one resonance (res), conjugated double or triple bond (conj) or aromatic ring (ar) property.
Two genes are defined as connected or correlated if the P-value of the expression correlation is less than 0.0001.
Regions of interest were defined as connected if a fibre originated in Region of interest 1 and terminated in Region of interest 2. These connections were weighted by streamline count and combined into a 76 × 76, undirected and weighted, structural connectivity matrix.
First, to quantify whether a complex is embedded within a highly-connected region of the PPI network, we derive EXT, the number of external proteins that are highly connected to it, defined as being connected to at least half of the proteins in the complex.
Network hubs are defined as highly connected genes within a network, having high intramodular connectivity.
However, the proportion of docked granules, defined as visually connected to the plasma membrane, was similar in wt and CgB-ko (9.3±3.5% and 9.8±3.3%, respectively).
A similar test was therefore performed for the hubs which are defined as highly connected proteins in an interaction network.
Currency metabolites were defined as highly connected metabolites of side reactions and included metabolites such as water, ATP, ADP and other co-factors.
In enzyme-centric networks, proteins are defined as nodes, connected by the metabolites they process, whilst metabolite-centric networks assign the metabolites to nodes and the processing enzymes to edges.
As a final measure to differentiate the roles of social interactions in determining population structure, we considered the number of sectors on the expanding front of each population, where sectors were defined as spatially connected cell clusters that are greater than one hundred cells from the same species.
