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A domain is defined as associated with a disease if the domain contains at least one nonsynonymous single nucleotide polymorphism (nsSNP) associated with the disease [ 22].
Death was defined as associated with A. baumannii infection if the patient had persistent manifestations of the infection and no other possible cause of death was detected.
In 17 cases (35%), deaths were defined as associated with A. baumannii infection, including the one occurring 52 days after the infection.
Interestingly in our study, more than 60% of coinfected patients had an AUC0-4h below the threshold of 1755 μg.h/L defined as associated with SVR in HCV monoinfected patients [ 17].
Using the Ingenuity software, canonical pathways were defined as associated with either ER- or ER+ ERBB2-amplified tumors (p < 0.05) (Additionnal file 1-Table S7D and Additionnal file 5-Figure S3).
Secondary childhood glaucoma is defined as associated with congenital ocular anomalies such as conditions associated with mesodermal dysgenesis of the neural crest, phakomatoses characterized by hamartomas, metabolic disorders, mitotic disorders, and other congenital disorders and associated with acquired conditions such as tumors, uveitis, and trauma [ 3].
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Possible confounders were defined as being associated with any exposure (Table 1) as well as being associated with children's anthropometric outcomes at age 5 years.
Sepsis was defined as SIRS associated with C. difficile-associated diarrhea.
Protective genes were defined as those associated with a hazard ratio (HR) of less than 1; risk genes were defined as those associated with a hazard ratio of more than 1.
Severe sepsis was defined as sepsis associated with either evidence of hypoperfusion with organ dysfunction or sepsis-induced hypotension.
A leukemoid reaction is defined as leukocytosis associated with a cause outside the bone marrow, with the white blood cell count (WBC) exceeding 50*10/L.
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