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Functional decline, often defined as a deterioration in the activities of daily living (ADL), is a result of reduced physiological reserves [ 5].
Mild cognitive impairment (MCI) is defined as a deterioration of memory, attention, and cognitive function that exceeds what is expected for an individual's age and education level.
Brain herniation was defined as a deterioration of consciousness accompanied by anisocoria or bilateral pupil dilation (excluding oculomotor nerve palsy caused by other diseases).
Functional decline is defined as a deterioration in self-care skills, where functional autonomy is diminished and disability is increased [ 5, 6].
Functional decline is defined as a deterioration of one or more activities of daily living (ADL) after discharge compared to premorbid ADL functioning, and has become an increasingly important focus of care during and after hospital admission as it is experienced by 15-50% of acutely hospitalized patients [ 7- 9].
Relapse is defined as a deterioration of >2 points on the CGI-Severity scale and a 25%% increase in the score on the Nisonger pivotal scale, compared to start of Study Period II (average of Visits 7 and 8), for at least two consecutive visits, 15 days apart.
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Reasons for discontinuation of ixazomib included disease progression (63%), AEs (10%) and symptomatic deterioration (10% defined as a global deterioration of health status without objective evidence of disease progression).
MOF was defined as a severe deterioration of at least two organ systems.
ARF was defined as a respiratory deterioration requiring assisted ventilation, due to an acute illness in a previously stable patient.
Type II neurologic damage was defined as: a new deterioration in intellectual function, confusion, agitation, disorientation, memory deficit, or a nonmetabolic seizure without evidence of focal injury.
Rebleeding was defined as a sudden deterioration in the level of consciousness or a sudden increase in headache, combined with an increase of blood on CT compared with the previous CT.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com