Sentence examples for defined alterations from inspiring English sources

Programmable nucleases allow defined alterations in the genome with ease-of-use, efficiency, and specificity.

In adenocarcinomas with defined alterations such as EGFR mutations and ALK translocations, targeted therapies are now first-line standard of care.

In each experiment, tumours with defined alterations in EGFR, HER-2/neu, or c-Kit were used as positive controls.

Next, we defined alterations as persistent if present within the same patient at all subsequent time points after the 'non-progenitor' isolate in which they are first identified.

These defined alterations are currently evaluated for their use as biomarkers for diagnosis, prognosis and prediction of therapy response for different cancers [101].

We used the R2: microarray analysis and visualization platform (http://r2.amc.nl) created by Dr. Jan Koster at the Academic Medical Center (AMC), Amsterdam, to examine the association of the metastamiRs' key targets, i.e., those that showed defined alterations in protein expression/phosphorylation with immunoblotting, with overall survival of patients with neuroblastoma.

Interestingly, the defined alteration of the device characteristics occurs at temperatures below the bulk-glass transition and therefore cannot be explained by changes of the charge carrier mobility but merely by the detected increase of the interface roughness.

To define alterations in the density of corneal basal epithelium in relation to diabetic retinopathic severity and the alteration of corneal innervation using confocal microscopy.

Previous studies have inferred that this detrimental immune response results from polarisation of the T helper (Th) response towards an anti-inflammatory, TH2 dominated, response at the expense of a bactericidal, Th1 response [1]. 1) To define alterations in TH cell subsets following severe blunt polytrauma.

Further studies are required to define alterations in larger, recent cohorts with less advanced disease, treated with specific ART regimens, and their possible association with HAND subtypes.

In this study, we use morphometric and FACS analyses to quantitatively define alterations in the fine structure of microglia during aging and in AD-like disease.