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We first analyzed the complete set of the collected GATA factors, using the conserved zinc finger domains and aligning newly identified factors to a previously defined alignment [ 6].
This pharmacophore could not be used for virtual screening since no defined alignment may be found for a pharmacophore presenting less than three independent features.
The original defined alignment of I-73 would have run along I-75 to Detroit.
Information from indels was only incorporated when these that had clearly defined alignment boundaries.
A polymer actuator was demonstrated by de Haan et al. 166 using polymerizable LCs combined with optically defined alignment layers.
Interestingly, aspects of Lis1's effects (e.g., constitutively strong microtubule binding and activated ATPase) have been achieved by locking the helices of the stalk's coiled coil in a defined alignment by crosslinking (Kon et al., 2009).
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Another difference is that the q-gram procedure defines alignment differences as an edit distance, where each nucleotide in a gap counts as a difference, so longer indels are considered more distant.
In the second section we define alignments formally and state a few main results on the statistics of local sequence alignment.
This μ-representation could also be used to define alignments between phylogenetic networks (Cardona et al., 2007, Section VI), which are useful in order to display at a glance the differences between alternative evolutionary histories of a set of species.
We calculated this proportion by summing up all bases that fall into alignment regions as defined by alignment start and end coordinates.
Fraction of read aligned is defined as (alignment length + insertions - deletions)/ alignment length + unaligned length - deletions + insertions).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com