By isolating and concatenating characteristic site residues, we defined adaptation signatures, which summarize the adaptive potential of specific isolates.
Since the dynamic part of the adaptation methodology proposed here is not currently implemented, we used simulation to predict how the defined adaptation strategy for the Adaptable-ASK system would behave in a real runtime situation.
The IPCC defined adaptation as measures that reduce the vulnerability of a system to climatic stress [12].
In the recent Brumme et al study on HIV [14] the authors defined adaptation as change occurring at an adaptation site within a known T-cell epitope (n = 71).
In the present study we defined adaptation as change within a published T-cell epitope (n = 96) or at a putative viral adaptation site (n = 36) in the NS2-NS5B regiof of which 9 sites were within known HCV T-cell epitopes.
However, most of these studies analysed steady-state situations, and to date it is still not clear if Dictyostelium specifically recognizes different types of bacteria and triggers defined adaptation pathways, or if the specific response occurs at a metabolic level, as an a posteriori adaptation to the different intracellular levels of available metabolites.
The fourth assessment report of the Intergovernmental Panel on Climate Change defined adaptation as an 'Adjustment in natural or human systems in response to actual or expected climatic stimuli or their effects, which moderates harm or exploits beneficial opportunities' —in contrast to mitigation which refers to action to reduce carbon emissions [ 1].
The combination of horizontal gene transfer, duplication, and rearrangement indicate that complex evolutionary processes account for the high level of HI gene cluster diversity in these bacteria, the products of which may provide a yet to be defined adaptation to the marine environment.
Thus, defining adaptations in relation to natural selection, and vice versa, results in tautology.
As expected, these filters define adaptation strategies that make the system practically fixed.
In (Nallur and Bahsoon 2013) the authors focus on a market-oriented programming strategy to define adaptation strategies.
