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These syndromes were defined according to guidelines established by the various specialty organizations.
MetS was defined according to guidelines from the US National Cholesterol Education Program Adult Treatment Panel III.
Clinical relevance of the differences was defined according to guidelines for the interpretation of the EORTC QLQ-C30 (Cocks et al, 2011) and according to Norman's rule of thumb for the FAS, indicating a ±0.5 s.d.
MS was defined according to guidelines by the International Diabetes Federation (IDF) [ 12], the only exception being that the BP criteria were used according to the North American Task Force guidelines [ 20].
The diagnosis of asthma was defined according to guidelines by the Global Initiative for Asthma (GINA) [ 20] (http://www.ginasthma.org/), and patients with all levels of asthma severity were recruited.
Risky drinking is defined according to guidelines set forth by the National Institute on Alcohol Abuse and Alcoholism: consuming >2 drinks per day for men or >1 drink per day for women; and >14 drinks per week for men or >7 drinks per week for women.
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MetS was defined according to recent guidelines from the National Cholesterol Education Program.
Clinical target volume (CTVprostate bed) was defined according to the guidelines as described by Poortmans et al. [35].
IE complications on ICU admission such as congestive heart failure, septic shock, and extra-cardiac involvement mainly due to systemic embolic events were defined according to current guidelines [13].
Acute lung injury (ALI) was defined according to current guidelines [26].
The clinical stage of the women and their children (available for 21 transmitting and 24 non transmitting mothers and for 26 out of 28 children respectively), was defined according to the guidelines of the Centers for Disease Control CDCC) [20], [21].
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CEO of Professional Science Editing for Scientists @ prosciediting.com