Sentence examples for defined a need from inspiring English sources

Government agencies have defined a need to reduce, refine or replace current mammalian-based bioassays with testing methods that use alternative species.

Patients may be unwilling to accept the AE burden and/or potential complications of adhering to monthly prophylactic MM/MRM therapies [15], defining a need for alternative treatment options among this population.

This clearly defines a need for long term follow-up for the development of essential hypertension in GH women.

5 These challenges define a need for additional combinations of therapeutics, ideally targeting complementary steps of the viral life cycle, with improved efficacy and safety.

Flares defined by a need to escalate immunosuppressive therapy were captured more frequently and earlier than flares defined by standard activity indices.

Flares defined by a need to escalate immunosuppressive therapy [(i), (ii)] were captured more frequently and earlier than flares defined by standard activity indices [(iii), (iv)] (Fig.  3).

Postresuscitation shock was defined as a need for intravenous vasoactive therapy (epinephrine or norepinephrine) for more than 6 h after ROSC despite adequate fluid loading.

Failure was defined as a need for advanced therapy.

Response to MTX was efficacy versus failure (defined as a need for MTX switch or escalation).

Subsequent ESRD was defined as a need for chronic dialysis for more than 90 days or a kidney transplant.

Major bleeding complications were defined as a need for transfusion, a reduction in hemoglobin of more than 40 g/L, or intracranial or retroperitoneal hemorrhage.