In order to describe the correspondence between condensed VAS data and the VRS categories, the continuous VAS assessments were transformed to a discrete five-category scale in two ways; the cut-off positions being defined unbiased relative the VRS assessments, and being defined equidistantly, respectively.
Here, we define the unbiased sequence selectivity of the tru pathway with the heptapeptide series.
Equation (1) defines an unbiased estimator for the fraction of mRNAs that represent the inclusion isoform under the assumption that splice-junction reads are distributed evenly.
The model for ligands was not included until their conformations were fully defined by unbiased | Fo| – | Fc| ϕcalc electron density maps.
The model for ligands was not included until their conformations were fully defined by unbiased | Fo| – | Fc|, φcalc electron density maps.
Ligand coordinates and topologies were produced with PRODRG [37]; ligands were not included until their conformations were completely defined by unbiased σA-weighted | Fo| − | Fc|, φcalc electron density maps.
This three-steps comparison approach requires (i) establishing a discriminant ratio and relative discriminant power; (ii) determining the maximum expected rank correlation with another test taking measurement noise into account; and (iii) defining an unbiased line of equivalence relating non-HDL-C to apoB.
However, detailed molecular/cellular immunological data from experiments carried out independently, in the main by basic research groups unconcerned with malaria (and therefore unbiased), define a mechanism of tolerogenic induction via the skin which strongly supports this conclusion.
To elucidate the proximal function of Parkin, we used quantitative proteomics to define, in an unbiased and highly comprehensive manner, how the mitochondrial proteome changes in response to Parkin activity.
We are aware of the poor statistical power of so small a group of controls, but it is reasonable to use a control group to define cut-off values, unbiased between sites.
